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KMID : 0378019710140040135
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New Medical Journal
1971 Volume.14 No. 4 p.135 ~ p.138
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Influence of ginseng upon adrenocortical DNA synthesis
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Abstract
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A study was carried out to see if the genseng has any influence upon adrenocortical DNA synthesis and to estimate the effect of ACTH upon the DNA synthetic activity of ginseng-primed adrenal cortex. Fourty male mice (body weight: 18-20 gm) were divided equally into the ginseng and the saline groups, which received for 5 days 0. 5 ml/100 gm body weight of ginseng extract solution(4 mg of ginseng alcohol extract in 1 ml of saline) per day or the same amount of saline, respectively. On the 5th experimental day, each of the 2 groups was further divided into 2 subgroups yielding the ginseng, the ginseng-ACTH,
the saline, and the saline-ACTH subgroups. All subgroups received a single dose of 3H-thymidine (0. 1 pCi/gm body weight, i. p.) 1 hour after the last medication (at 0900). The ginseng and the saline subgroups were sacrificed 3 hours after the last medication, while the ginseng-ACTH, and the saline￢ACTH subgroups received ACTH (0. 1 unit/subject) 1 hour after the last medication and were sacrificed after 2 more hours. Adrenocortical synthetic activity of DNA was estimated autoradiographically by .I counting the number of labeled cells in 1,000 cell counts.
Following results were obtained
1. Labeled adrenocortical cells were significantly more numerous in the ginseng group than in the saline group.
2. Both the ginseng-ACTH and the saline-ACTH groups had reduced number of labeled cells compared with what the ginseng and the saline groups had, respectively. However, the reduction was less conspicuous in the ginseng group compared with that in the saline group.
Fran the above results, the ginseng s inferred to facilitate adrenocortical DNA synthesis significantly and to mitigate drop in DNA synthesis following administration of ACTH.
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